Substance P 1-7

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

P物质1-7是速激肽P物质（SP）蛋白水解降解后形成的主要生物活性代谢产物，具有抗炎、抗伤害和抗痛觉过敏作用。

Substance P 1-7 is the major bioactive metabolite formed after proteolytic degradation of the tachykinin substance P (SP)with anti-inflammatory anti-nociceptive and anti-hyperalgesic effects.

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Substance P (1-7) is found to act as a very potent antagonist against the SP-induced responses and is formed locally in the nigra after SP injection. It is proposed that Substance P (1-7) is an endogenous modulator of SP actions. Injection of low doses of Substance P (1-7) (1.0-4.0 pM simultaneously with SP or SP(5-11) (0.1 nM), reduce aversive behaviours induced by SP or SP(5- 11) significantly. These results indicate that SP(1-7) formed endogenously could modulate the actions of SP or SP(5-11) in the spinal cord.

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Others

Other Targets

Others

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68060-49-1

900.04

C41H65N13O10

>98% (HPLC)

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N=C(N)NCCCC(N)C(=O)N1CCCC1C(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(CCC(N)=O)C(=O)NC(CCC(N)=O)C(=O)NC(Cc1ccccc1)C(=O)O

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(-20℃)

With Ice Pack

≥ 2 years